3-Furanol, tetrahydro- → HCID 66576410, compound

HRID 1775599Notes

Reaction equation

HRID 1775599 reaction equation
[Cl:1][C:2]1[C:7]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[N:6][N:5]=[C:4]2[NH:14][N:15]=[C:16]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=3)[C:3]=12.O[CH:24]1[CH2:28][CH2:27][O:26][CH2:25]1>>[Cl:1][C:2]1[C:7]([C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=2)=[N:6][N:5]=[C:4]2[N:14]([CH:24]3[CH2:28][CH2:27][O:26][CH2:25]3)[N:15]=[C:16]([C:17]3[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=3)[C:3]=12

Participants

3

Reactant 2

HCID 99603-Furanol, tetrahydro-HCID 86697018CID 86697018

Product 1

HCID 66576410HCID 66576410, compoundYield 34.8%

Procedure

Compound 97 was synthesised from 4-chloro-3,5-diphenyl-1H-pyrazolo[3,4-c]pyridazine (50 mg, 0.16 mmol) following a similar procedure outlined in Example 86, using 3-hydroxytetrahydrofuran (28 mg, 0.32 mmol) instead of oxetan-3-ol. Compound 97 was purified using preparative HPLC followed by chromatography (silica gel, gradient CH2Cl2), yielding Compound 97 as an off-white solid (21 mg).

Workup

  1. customCompound 97 was purified

Sources & evidence

ORD record
ord-e3ca3b6b650e4bd8a76ec614ffba1fb3
Source dataset
uspto-grants-2016_02
Patent number
US09260381B2

Reaction notes

Loading…