Allylamine → HCID 86729813, compound

HRID 1775692Notes

Reaction equation

HRID 1775692 reaction equation
[C:1]1([N:7]2[C:12](=[O:13])[C:11]3[S:14][CH:15]=[C:16]([C:17]4[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=4)[C:10]=3[N:9]=[CH:8]2)C=CC=[CH:3][CH:2]=1.NC1C(C2C=CC=CC=2[F:35])=CSC=1C(OC)=O.C(OCC)(OCC)OCC.C(N)C=C>C(O)(=O)C>[CH2:1]([N:7]1[C:12](=[O:13])[C:11]2[S:14][CH:15]=[C:16]([C:17]3[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=3[F:35])[C:10]=2[N:9]=[CH:8]1)[CH:2]=[CH2:3]

Participants

6

Reactant 4

HCID 7853AllylamineHCID 31214Ethyl orthoformateHCID 533358861325307-27-4HCID 783248653,7-Diphenylthieno[3,2-d]pyrimidin-4(3H)-one

Product 1

HCID 86729813HCID 86729813, compoundYield 10.2%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

In the same manner as the synthesis of Compound 1, methyl 3-amino-4-(2-fluorophenyl)thiophene-2-carboxylate (100 mg, 0.40 mmol), triethyl orthoformate (1.0 ml), allylamine (86 mg, 0.92 mmol), and acetic acid (0.1 ml) were used to give 11.7 mg (0.04 mmol, 10.2% yield) of the title compound.

Sources & evidence

ORD record
ord-b158ba3a3f624c89bd69325ff831d795
Source dataset
uspto-grants-2016_02
Patent number
US09260448B2

Reaction notes

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