Hydrochloric Acid → HCID 89653240, compound

HRID 1775784Notes

Reaction equation

HRID 1775784 reaction equation
C([S:4][CH2:5][CH2:6][O:7][CH2:8][CH2:9][O:10][CH2:11][CH2:12][O:13][CH2:14][CH2:15][O:16][CH2:17][CH2:18][O:19][CH2:20][CH2:21][N-:22]C(=O)C(F)(F)F)(=O)C.CO.C[O-].[Na+].[ClH:34]>O>[ClH:34].[NH2:22][CH2:21][CH2:20][O:19][CH2:18][CH2:17][O:16][CH2:15][CH2:14][O:13][CH2:12][CH2:11][O:10][CH2:9][CH2:8][O:7][CH2:6][CH2:5][SH:4]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 10942334Sodium MethoxideHCID 178477134HCID 178477134, compound

Product 1

HCID 89653240HCID 89653240, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A solution of compound 16 in 1 ml of abs. MeOH was cooled to −40° C., and admixed with 1.3 ml of freshly prepared NaOMe solution (cooled to −40° C., 1.3 mM). The solution was warmed to RT over the course of 30 min, admixed with 1 ml of H2O, and adjusted to a pH of 6 after 20 min with 1M HCl, and the solvent was removed. The residue was used without further purification.

Workup

  1. customthe solvent was removed
  2. customThe residue was used without further purification

Sources & evidence

ORD record
ord-16c397a18d7a4a79a3fd76152b38acf9
Source dataset
uspto-grants-2016_02
Patent number
US09260467B2

Reaction notes

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