Hydrochloric Acid → HCID 58016057, compound

Participants

Reaction Steps

Ethyl 2-iodo-4-phenyl-1,3-thiazole-5-carboxylate (5 g, 13.9 mmol) was dissolved in 96% ethanol (30 ml), treated with solid sodium hydroxide (1.1 g) and stirred at room temperature for 1 hour. The solution was acidified with 3 N HCl solution, and extracted with ethyl acetate (5×50 ml). The organic layers were combined, dried over Na2SO4 and evaporated to give the title compound as a solid. Yield: 92% yield.

Provenance & Evidence