Hydrochloric Acid → HCID 58016057, compound

HRID 1776152Notes

Reaction equation

HRID 1776152 reaction equation
[I:1][C:2]1[S:3][C:4]([C:13]([O:15]CC)=[O:14])=[C:5]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[N:6]=1.[OH-].[Na+].Cl>C(O)C>[I:1][C:2]1[S:3][C:4]([C:13]([OH:15])=[O:14])=[C:5]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[N:6]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 58016070HCID 58016070, compound

Product 1

HCID 58016057HCID 58016057, compoundYield 92%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Ethyl 2-iodo-4-phenyl-1,3-thiazole-5-carboxylate (5 g, 13.9 mmol) was dissolved in 96% ethanol (30 ml), treated with solid sodium hydroxide (1.1 g) and stirred at room temperature for 1 hour. The solution was acidified with 3 N HCl solution, and extracted with ethyl acetate (5×50 ml). The organic layers were combined, dried over Na2SO4 and evaporated to give the title compound as a solid. Yield: 92% yield.

Workup

  1. extractionextracted with ethyl acetate (5×50 ml)
  2. dry with materialdried over Na2SO4
  3. customevaporated

Sources & evidence

ORD record
ord-7bd9cff26ea944f699ee4be1fcc0dfc1
Source dataset
uspto-grants-2016_02
Patent number
US09265769B2

Reaction notes

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