Potassium Hydroxide → HCID 86702145, compound

HRID 1776215Notes

Reaction equation

HRID 1776215 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]2[NH:6][C:7]3[C:12]([C:13]=2[CH:14]=1)=[CH:11][C:10]([F:15])=[CH:9][CH:8]=3.[OH-].[K+].Cl[CH2:19][C:20]1([CH3:23])[CH2:22][O:21]1>CN(C)C=O>[F:15][C:10]1[CH:9]=[CH:8][C:7]2[N:6]([CH2:19][C:20]3([CH3:23])[CH2:22][O:21]3)[C:5]3[C:13]([C:12]=2[CH:11]=1)=[CH:14][C:2]([F:1])=[CH:3][CH:4]=3

Participants

5

Reactant 3

HCID 14797Potassium HydroxideHCID 952202-(Chloromethyl)-2-methyloxiraneHCID 867021373,6-Difluorocarbazole

Product 1

HCID 86702145HCID 86702145, compoundYield 63.5%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

To a stirred solution of 3,6-difluoro-9H-carbazole (2.0 g, 9.8 mmol) in N,N-dimethylformamide (50 mL) at 0° C. was added 85% potassium hydroxide (0.780 g, 11.8 mmol) and the mixture was stirred for 1 hr. 2-(Chloromethyl)-2-methyloxirane (2.098 g, 19.7 mmol) was added and the mixture was slowly warmed to room temperature and stirred for 16 hrs. The mixture was partitioned between water and ethyl acetate. The organic layer was washed with saturated aqueous sodium chloride, dried (anhydrous sodium sulfate), filtered, and concentrated in vacuo. The residue was purified by silica gel chromatography (10-50% methylene chloride/hexanes) to afford the desired product as a white solid (1.7 g, 63%). 1H NMR (300 MHz, CDCl3) δ 7.68 (dd, 2H, J=8.4, 2.4 Hz), 7.41 (dd, 2H, J=9.0, 4.2 Hz), 7.23 (td, 2H, J=9.0, 2.4 Hz), 4.62 and 4.22 (AB, 2H, J=15.6 Hz), 2.71 & 2.66 (AB, 2H, J=4.5 Hz), 1.33 (s, 3H).

Workup

  1. stirringstirred for 16 hrs
  2. customThe mixture was partitioned between water and ethyl acetate
  3. washThe organic layer was washed with saturated aqueous sodium chloride
  4. dry with materialdried (anhydrous sodium sulfate)
  5. filtrationfiltered
  6. concentrationconcentrated in vacuo
  7. customThe residue was purified by silica gel chromatography (10-50% methylene chloride/hexanes)

Sources & evidence

ORD record
ord-718f312d8e6c4a82890e50fa373e4999
Source dataset
uspto-grants-2016_02
Patent number
US09265772B2

Reaction notes

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