反应详情

温度

80 °C

To a stirred solution of PPA (2.0 g, 20 mmol) were added 2-(4-(quinolin-2-ylmethoxy)phenyl)acetyl chloride (2.0 g, 5.0 mmol) and anisole (1.0 g, 10 mmol) at RT under an inert atmosphere. The reaction mixture was then heated at 80° C. for 3 h, quenched with ice cold water and stirred for another 10 minutes. The precipitated solid was filtered, and then the solid was stirred in 10% NaOH solution for 1 h, extracted with DCM (2×50 mL). The combined organic layers were washed with water (2×10 mL) and brine, concentrated, and dried under vacuum to afford 1-(4-methoxyphenyl)-2-(4-(quinolin-2-ylmethoxy)phenyl)ethanone (1.85 g, 90%) as a solid.

1. customquenched with ice cold water
2. filtrationThe precipitated solid was filtered
3. stirringthe solid was stirred in 10% NaOH solution for 1 h
4. extractionextracted with DCM (2×50 mL)
5. washThe combined organic layers were washed with water (2×10 mL) and brine
6. concentrationconcentrated
7. customdried under vacuum