Hydrochloric Acid → HCID 86732447, compound

Participants

Reaction Steps

150 mg of 2-[1-(4-ethoxy-2,6-difluorobenzyl)-1H-indazol-3-yl]-5-methoxy-N-(pyridin-4-yl)pyrimidin-4-amine (2-5-1, 0.307 mmol, 1. eq.) were dissolved in a mixture of 5.9 ml of dry dichloromethane and 2.5 ml of dry methanol. 0.25 ml of 1.25 M hydrogen chloride solution in methanol were added. The mixture was stirred at room temperature for 1 hour. Then the mixture was concentrated in vacuo to yield 161 mg (0.29 mmol, 95.9%) of the analytically pure target compound.

Provenance & Evidence