Hydrochloric Acid → HCID 86732447, compound

HRID 1776418Notes

Reaction equation

HRID 1776418 reaction equation
[CH2:1]([O:3][C:4]1[CH:34]=[C:33]([F:35])[C:7]([CH2:8][N:9]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[C:11]([C:18]3[N:23]=[C:22]([NH:24][C:25]4[CH:30]=[CH:29][N:28]=[CH:27][CH:26]=4)[C:21]([O:31][CH3:32])=[CH:20][N:19]=3)=[N:10]2)=[C:6]([F:36])[CH:5]=1)[CH3:2].[ClH:37]>ClCCl.CO>[ClH:37].[CH2:1]([O:3][C:4]1[CH:5]=[C:6]([F:36])[C:7]([CH2:8][N:9]2[C:17]3[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=3)[C:11]([C:18]3[N:23]=[C:22]([NH:24][C:25]4[CH:30]=[CH:29][N:28]=[CH:27][CH:26]=4)[C:21]([O:31][CH3:32])=[CH:20][N:19]=3)=[N:10]2)=[C:33]([F:35])[CH:34]=1)[CH3:2]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 86732433HCID 86732433, compound

Product 1

HCID 86732447HCID 86732447, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolvent2×HCID 6344DichloromethaneSolvent

Procedure

150 mg of 2-[1-(4-ethoxy-2,6-difluorobenzyl)-1H-indazol-3-yl]-5-methoxy-N-(pyridin-4-yl)pyrimidin-4-amine (2-5-1, 0.307 mmol, 1. eq.) were dissolved in a mixture of 5.9 ml of dry dichloromethane and 2.5 ml of dry methanol. 0.25 ml of 1.25 M hydrogen chloride solution in methanol were added. The mixture was stirred at room temperature for 1 hour. Then the mixture was concentrated in vacuo to yield 161 mg (0.29 mmol, 95.9%) of the analytically pure target compound.

Workup

  1. concentrationThen the mixture was concentrated in vacuo
  2. customto yield 161 mg (0.29 mmol, 95.9%) of the analytically pure target compound

Sources & evidence

ORD record
ord-189e738fafcb4173aaf045e67a8e132a
Source dataset
uspto-grants-2016_02
Patent number
US09265763B2

Reaction notes

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