Morpholine → HCID 86679434, compound

HRID 1776484Notes

Reaction equation

HRID 1776484 reaction equation
C1C2C(COC([NH:18][C@H:19]([CH2:49][CH2:50][CH2:51][O:52][C:53](=[O:55])[CH3:54])[C:20]([O:22][C@H:23]([C:34]3[CH:39]=[CH:38][C:37]([O:40][CH:41]([F:43])[F:42])=[C:36]([O:44][CH2:45][CH:46]4[CH2:48][CH2:47]4)[CH:35]=3)[CH2:24][C:25]3[C:30]([Cl:31])=[CH:29][N+:28]([O-:32])=[CH:27][C:26]=3[Cl:33])=[O:21])=O)C3C(=CC=CC=3)C=2C=CC=1.N1CCOCC1>C(Cl)Cl>[C:53]([O:52][CH2:51][CH2:50][CH2:49][C@@H:19]([NH2:18])[C:20]([O:22][C@H:23]([C:34]1[CH:39]=[CH:38][C:37]([O:40][CH:41]([F:42])[F:43])=[C:36]([O:44][CH2:45][CH:46]2[CH2:48][CH2:47]2)[CH:35]=1)[CH2:24][C:25]1[C:26]([Cl:33])=[CH:27][N+:28]([O-:32])=[CH:29][C:30]=1[Cl:31])=[O:21])(=[O:55])[CH3:54]

Participants

4

Reactant 2

HCID 8083MorpholineHCID 86679435HCID 86679435, compound

Product 1

HCID 86679434HCID 86679434, compoundYield 100%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

To a solution of 4-((S)-2-((R)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-5-acetoxypentanoyloxy)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-ethyl)-3,5-dichloropyridine 1-oxide (284 mg, 0.355 mmol) dissolved in DCM (5.7 ml), morpholine (615 μl, 7.10 mmol) was added. The mixture was stirred at RT for 48 hours. The mixture was then diluted with DCM and washed twice with water. The organic phase was dried over Na2SO4 and the solvent was evaporated, to yield 205 mg of the title compound.

Workup

  1. washwashed twice with water
  2. dry with materialThe organic phase was dried over Na2SO4
  3. customthe solvent was evaporated

Sources & evidence

ORD record
ord-9a47042c85074cd387692f674c167823
Source dataset
uspto-grants-2016_02
Patent number
US09265768B2

Reaction notes

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