Morpholine → HCID 86679434, compound

Participants

Reaction Steps

To a solution of 4-((S)-2-((R)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-5-acetoxypentanoyloxy)-2-(3-(cyclopropylmethoxy)-4-(difluoromethoxy)phenyl)-ethyl)-3,5-dichloropyridine 1-oxide (284 mg, 0.355 mmol) dissolved in DCM (5.7 ml), morpholine (615 μl, 7.10 mmol) was added. The mixture was stirred at RT for 48 hours. The mixture was then diluted with DCM and washed twice with water. The organic phase was dried over Na2SO4 and the solvent was evaporated, to yield 205 mg of the title compound.

Provenance & Evidence