HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2-(Methyl(4-(methylsulfonamido)benzyl)amino)acetic acid hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Methyl 2-(methyl(4-(methylsulfonamido)benzyl)amino)acetate | HCID 86679452 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 2-(Methyl(4-(methylsulfonamido)benzyl)amino)acetic acid hydrochloride | HCID 86679453 | 100% |
Reaction Steps
A solution of methyl 2-(methyl(4-(methylsulfonamido)benzyl)amino)acetate (0.977 g, 3.41 mmol) and HCl 6N (14.22 ml, 85 mmol) in dioxane (100 ml) was heated at 70° C. overnight. The solvent was removed and crude 2-(methyl(4-(methylsulfonamido)-benzyl)amino)acetic acid hydrochloride was obtained (1.054 g, 3.41 mmol, 100% yield, MS/ESI+ 273.1 [MH]+) and used in the next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09265768B2 |
| Source dataset | uspto-grants-2016_02 |
| ORD ID | ord-31e8e230fbfa4342851798357dc77a44 |
| Source note | uspto-grants-2016_02 |