Hydrochloric Acid → 2-(Methyl(4-(methylsulfonamido)benzyl)amino)acetic acid hydrochloride

HRID 1776505Notes

Reaction equation

HRID 1776505 reaction equation
[CH3:1][N:2]([CH2:8][C:9]1[CH:14]=[CH:13][C:12]([NH:15][S:16]([CH3:19])(=[O:18])=[O:17])=[CH:11][CH:10]=1)[CH2:3][C:4]([O:6]C)=[O:5].[ClH:20]>O1CCOCC1>[ClH:20].[CH3:1][N:2]([CH2:8][C:9]1[CH:14]=[CH:13][C:12]([NH:15][S:16]([CH3:19])(=[O:18])=[O:17])=[CH:11][CH:10]=1)[CH2:3][C:4]([OH:6])=[O:5]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86679452Methyl 2-(methyl(4-(methylsulfonamido)benzyl)amino)acetate

Product 1

HCID 866794532-(Methyl(4-(methylsulfonamido)benzyl)amino)acetic acid hydrochlorideYield 100%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A solution of methyl 2-(methyl(4-(methylsulfonamido)benzyl)amino)acetate (0.977 g, 3.41 mmol) and HCl 6N (14.22 ml, 85 mmol) in dioxane (100 ml) was heated at 70° C. overnight. The solvent was removed and crude 2-(methyl(4-(methylsulfonamido)-benzyl)amino)acetic acid hydrochloride was obtained (1.054 g, 3.41 mmol, 100% yield, MS/ESI+ 273.1 [MH]+) and used in the next step without further purification.

Workup

  1. customThe solvent was removed

Sources & evidence

ORD record
ord-31e8e230fbfa4342851798357dc77a44
Source dataset
uspto-grants-2016_02
Patent number
US09265768B2

Reaction notes

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