Potassium Carbonate → Methyl 4-(cyclopropylmethoxy)-3-formylbenzoate

Participants

Reaction Steps

To a solution of methyl 3-formyl-4-hydroxybenzoate (2 g, 11.10 mmol) in DMF (20 ml), K2CO3 (3.07 mg, 22.2 mmol) and (bromomethyl)cyclopropane (2.156 ml, 22.2 mmol) were added. The mixture was stirred at RT for 2 hours. The reaction was quenched with water, and the product was extracted with EtOAc. The organic layer was washed with water (2×) and NaCl sat. sol., dried over Na2SO4 and evaporated under vacuum to give 2.6 g of the desired compound (quantitative yield).

Provenance & Evidence