Methanesulfonyl chloride → HCID 67025933, compound

HRID 1776628Notes

Reaction equation

HRID 1776628 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][CH2:9][C:10]([O:12][CH3:13])=[O:11])=[CH:4][CH:3]=1.[CH3:14][S:15](Cl)(=[O:17])=[O:16]>C(Cl)Cl.N1C=CC=CC=1>[CH3:14][S:15]([NH:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][CH2:9][C:10]([O:12][CH3:13])=[O:11])=[CH:6][CH:7]=1)(=[O:17])=[O:16]

Participants

5

Reactant 2

HCID 31297Methanesulfonyl chlorideHCID 417374Methyl 3-(4-aminophenyl)propanoate

Product 1

HCID 67025933HCID 67025933, compound

Reagents, catalysts & solvents 2

HCID 1049PyridineSolventHCID 6344DichloromethaneSolvent2×

Procedure

Methyl 3-(4-aminophenyl)propanoate (250 mg, 1.39 mmol) was dissolved in DCM (2 ml) and pyridine (500 μl), then methanesulfonyl chloride was added (191 mg, 1.67 mmol), and the mixture was stirred at RT for 2 hours. The reaction was diluted with DCM, and the organic phase was washed with HCl 1N (2×) and brine, dried over Na2SO4 and evaporated under vacuum to give 250 mg of the desired product.

Workup

  1. washthe organic phase was washed with HCl 1N (2×) and brine
  2. dry with materialdried over Na2SO4
  3. customevaporated under vacuum

Sources & evidence

ORD record
ord-2956a8545a2c41b9b1eba60ad6e85365
Source dataset
uspto-grants-2016_02
Patent number
US09265768B2

Reaction notes

Loading…