Benzyl Bromide → HCID 86282054, compound

HRID 1776734Notes

Reaction equation

C([N:8]1[C:12]2[CH:13]=[C:14]([O:17][CH2:18][C:19]3[CH:28]=[CH:27][C:26]4[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=4)[N:20]=3)[CH:15]=[CH:16][C:11]=2[N:10]=[C:9]1[CH2:29][C:30]([CH3:37])([CH3:36])[C:31]([O:33]CC)=[O:32])C1C=CC=CC=1.Br[CH2:39][C:40]1[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=1>>[CH2:39]([N:10]1[C:11]2[CH:16]=[CH:15][C:14]([O:17][CH2:18][C:19]3[CH:28]=[CH:27][C:26]4[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=4)[N:20]=3)=[CH:13][C:12]=2[N:8]=[C:9]1[CH2:29][C:30]([CH3:37])([CH3:36])[C:31]([OH:33])=[O:32])[C:40]1[CH:45]=[CH:44][CH:43]=[CH:42][CH:41]=1

Participants

Reactant 2

HCID 7498Benzyl Bromide

HCID 90416404HCID 90416404, compound

Product 1

HCID 86282054HCID 86282054, compound

Procedure

The title compound was prepared using analogous conditions described in Example 64 using ethyl 3-(1-benzyl-6-(quinolin-2-ylmethoxy)-1H-benzo[d]imidazol-2-yl)-2,2-dimethylpropanoate and (bromomethyl)benzene in Step A. MS (ESI): mass calcd. for C29H27N3O3, 465.21; m/z found, 466.0 [M+H]+. 1H NMR (400 MHz, CDCl3) δ 8.13-7.94 (m, 2H), 7.80-7.65 (m, 2H), 7.63-7.47 (m, 2H), 7.34-7.04 (m, 4H), 6.99-6.73 (m, 4H), 5.21 (s, 4H), 3.03 (s, 2H), 1.14 (s, 6H).

Sources & evidence

ORD record: ord-7584cf22e947426588655f8a93125cbf
Source dataset: uspto-grants-2016_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09265770B2

Reaction notes

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