Methanol → HCID 31699716, compound

HRID 1777065Notes

Reaction equation

HRID 1777065 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([S:8]([C:11]2[CH:12]=[C:13]([CH:17]=[CH:18][CH:19]=2)[C:14]([OH:16])=[O:15])(=[O:10])=[O:9])[CH2:4][CH2:3]1.S(=O)(=O)(O)O.[CH3:25]O>>[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([S:8]([C:11]2[CH:12]=[C:13]([CH:17]=[CH:18][CH:19]=2)[C:14]([O:16][CH3:25])=[O:15])(=[O:10])=[O:9])[CH2:4][CH2:3]1

Participants

4

Reactant 3

HCID 887MethanolHCID 1118Sulfuric AcidHCID 1081456380339-63-9

Product 1

HCID 31699716HCID 31699716, compound

Procedure

3-((4-methylpiperazin-1-yl)sulfonyl)benzoic acid (250 mg, 0.879 mmol) was refluxed in the presence of concentrated sulfuric acid (5.68 mg, 0.044 mmol) in methanol at 70° C. for overnight. Reaction was monitored by TLC. After completion of the reaction, solvent was removed by vacuum and the crude material was used for further reaction without purification.

Workup

  1. customReaction
  2. customAfter completion of the reaction, solvent
  3. customwas removed by vacuum
  4. customthe crude material was used for further reaction without purification

Sources & evidence

ORD record
ord-bae0fabb4ea647a8845097414d1ade20
Source dataset
uspto-grants-2016_02
Patent number
US09266838B2

Reaction notes

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