HCID 90241046, compound → HCID 90241000, compound

HRID 1777179Notes

Reaction equation

HRID 1777179 reaction equation
[CH2:1]([O:3][C:4](=[O:24])[CH2:5][O:6][C:7]1[CH:16]=[CH:15][CH:14]=[C:13]2[C:8]=1[CH2:9][CH2:10][N:11](C(OC(C)(C)C)=O)[CH2:12]2)[CH3:2]>C(OCC)(=O)C>[CH2:12]1[C:13]2[C:8](=[C:7]([O:6][CH2:5][C:4]([O:3][CH2:1][CH3:2])=[O:24])[CH:16]=[CH:15][CH:14]=2)[CH2:9][CH2:10][NH:11]1

Participants

3

Reactant 1

HCID 90241046HCID 90241046, compound

Product 1

HCID 90241000HCID 90241000, compoundYield 98.2%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Conditions

Temperature
25 °C

Procedure

To a solution of tert-butyl 5-(2-ethoxy-2-oxoethoxy)-3,4-dihydroisoquinoline-2(1H)-carboxylate (400 mg, 1.19 mmol) in ethyl acetate (10 mL), cooled in an ice-water bath, was added (10 mL, 1N) drop wise. The mixture was stirred at 25° C. for 16 h and then concentrated under vacuum to give the crude product (275 mg, 98%) which was used to the next step without further purification.

Workup

  1. additionwas added (10 mL, 1N) drop wise
  2. concentrationconcentrated under vacuum

Sources & evidence

ORD record
ord-89a015e037ac4f6dbcb95b1c1a1b65f1
Source dataset
uspto-grants-2016_02
Patent number
US09266836B2

Reaction notes

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