反应详情

A solution of tert-butyl 2-(5-cyano-2-oxoindolin-3-yl)-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylate (73 mg, 0.187 mmol) in 4N HCl in dioxane (5 mL) was stirred at RT for 3 h. After this period all volatiles were removed in vacuo. The residue was dissolved in water and washed with ethyl acetate. The aqueous layer was neutralized with saturated solution of sodium bicarbonate and extracted with ethyl acetate. The latter extracts were dried over sodium sulfate, filtered, and evaporated to dryness. Quant. yield.

1. customAfter this period all volatiles were removed in vacuo
2. dissolutionThe residue was dissolved in water
3. washwashed with ethyl acetate
4. extractionextracted with ethyl acetate
5. dry with materialThe latter extracts were dried over sodium sulfate
6. filtrationfiltered
7. customevaporated to dryness