Iodoethane → HCID 86670459, compound

HRID 1777280Notes

Reaction equation

HRID 1777280 reaction equation
I[CH2:2][CH3:3].[C:4]([O:8][C:9]([NH:11][CH2:12][C@H:13]([NH:18]CC)[C:14]([O:16][CH3:17])=[O:15])=[O:10])([CH3:7])([CH3:6])[CH3:5]>>[C:4]([O:8][C:9]([NH:11][CH2:12][C@@:13]([NH2:18])([CH2:2][CH3:3])[C:14]([O:16][CH3:17])=[O:15])=[O:10])([CH3:7])([CH3:6])[CH3:5]

Participants

3

Reactant 2

HCID 6340IodoethaneHCID 86670460HCID 86670460, compound

Product 1

HCID 86670459HCID 86670459, compound

Procedure

In a manner similar to Example 1-1, starting from 500 mg (2 mmol) of methyl (S)-2-amino-3-tert-butoxy-carbonyl-aminopropanoate hydrochloride and from 870 mg (6.3 mmol) of iodoethane, 192 mg (40%) of methyl (S)-3-tert-butoxycarbonylamino-2-ethylaminopropanoate are obtained in the form of a yellow oil.

Workup

  1. customare obtained in the form of a yellow oil

Sources & evidence

ORD record
ord-3d9d09ed5c9345619b2acc02c7611411
Source dataset
uspto-grants-2016_02
Patent number
US09266848B2

Reaction notes

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