Hydrochloric Acid → HCID 58970539, compound

HRID 1777351Notes

Reaction equation

HRID 1777351 reaction equation
Cl.C(OC([N:9]1[CH2:14][CH2:13][C:12]([CH2:18][CH:19]([CH3:21])[CH3:20])([C:15]([OH:17])=[O:16])[CH2:11][CH2:10]1)=O)(C)(C)C>O1CCOCC1>[CH2:18]([C:12]1([C:15]([OH:17])=[O:16])[CH2:11][CH2:10][NH:9][CH2:14][CH2:13]1)[CH:19]([CH3:21])[CH3:20]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 57790581944142-61-4

Product 1

HCID 58970539HCID 58970539, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A solution of hydrochloric acid (12N, 1.2 mL) in 1,4-dioxane (2.4 mL) is added to 4-isobutylpiperidine-1,4-dicarboxylic acid monotertbutyl ester (0.7 g, 0.0025 mol) and stirred at room temperature for 1 hr. The reaction mixture is concentrated under reduced pressure and the residue is treated with saturated solution of sodium bicarbonate (0.5 mL) to adjust the pH to ˜7. It is again concentrate under reduced pressure to get crude 4-isobutylpiperidine-4-carboxylic acid.

Workup

  1. concentrationThe reaction mixture is concentrated under reduced pressure
  2. additionthe residue is treated with saturated solution of sodium bicarbonate (0.5 mL)
  3. concentrationIt is again concentrate under reduced pressure

Sources & evidence

ORD record
ord-f1695c4a314746b992d4439a3af5c3e0
Source dataset
uspto-grants-2016_02
Patent number
US09266867B2

Reaction notes

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