Acetic Acid → HCID 66561899, compound

HRID 1777363Notes

Reaction equation

HRID 1777363 reaction equation
C(O)(=O)C.C(N)(C)(C)C.[Cl:10][C:11]1[CH:12]=[C:13]([C:21]2[O:25][N:24]=[C:23]([C:26]3[CH:42]=[CH:41][C:29]([CH2:30][N:31]4[CH2:36][CH2:35][C:34]([CH3:40])([C:37]([OH:39])=[O:38])[CH2:33][CH2:32]4)=[CH:28][CH:27]=3)[N:22]=2)[CH:14]=[CH:15][C:16]=1[CH2:17][CH:18]([CH3:20])[CH3:19]>O>[Cl:10][C:11]1[CH:12]=[C:13]([C:21]2[O:25][N:24]=[C:23]([C:26]3[CH:42]=[CH:41][C:29]([CH2:30][N:31]4[CH2:36][CH2:35][C:34]([CH3:40])([C:37]([OH:39])=[O:38])[CH2:33][CH2:32]4)=[CH:28][CH:27]=3)[N:22]=2)[CH:14]=[CH:15][C:16]=1[CH2:17][CH:18]([CH3:20])[CH3:19]

Participants

4

Reactant 2

HCID 176Acetic AcidHCID 66574515HCID 66574515, compound

Product 1

HCID 66561899HCID 66561899, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

An aqueous solution of 20% acetic acid (1 mL) is added to a slurry of 1-{4-[5-(3-chloro-4-isobutylphenyl)-[1,2,4]-oxadiazol-3-yl]-benzyl}-4-methylpiperidine-4-carboxylic acid t-butyl amine salt (0.2 g, 0.00035 mol) in demineralized water (10 mL) to adjust the pH of the solution to 4-5. The solution is stirred at room temperature for 30 minutes, filtered and washed with demineralized water (2×5 mL) & acetone (1×5 mL). Finally it is dried to get 1-{4-[5-(3-chloro-4-isobutylphenyl)-[1,2,4]-oxadiazol-3-yl]-benzyl}-4-methylpiperidine-4-carboxylic acid as free acid.

Workup

  1. filtrationfiltered
  2. washwashed with demineralized water (2×5 mL) & acetone (1×5 mL)
  3. customFinally it is dried

Sources & evidence

ORD record
ord-21d49b6b39a347eeb530e39cbfefbef8
Source dataset
uspto-grants-2016_02
Patent number
US09266867B2

Reaction notes

Loading…