Acetic Acid → HCID 66561899, compound

Participants

Reaction Steps

An aqueous solution of 20% acetic acid (1 mL) is added to a slurry of 1-{4-[5-(3-chloro-4-isobutylphenyl)-[1,2,4]-oxadiazol-3-yl]-benzyl}-4-methylpiperidine-4-carboxylic acid t-butyl amine salt (0.2 g, 0.00035 mol) in demineralized water (10 mL) to adjust the pH of the solution to 4-5. The solution is stirred at room temperature for 30 minutes, filtered and washed with demineralized water (2×5 mL) & acetone (1×5 mL). Finally it is dried to get 1-{4-[5-(3-chloro-4-isobutylphenyl)-[1,2,4]-oxadiazol-3-yl]-benzyl}-4-methylpiperidine-4-carboxylic acid as free acid.

Provenance & Evidence