Ethyl oxoacetate → HCID 118020508, compound

HRID 1777376Notes

Reaction equation

HRID 1777376 reaction equation
[C:1]([O:5][CH2:6][CH3:7])(=[O:4])[CH:2]=[O:3].[NH2:8][CH2:9][C@@H:10](O)[CH3:11].[CH3:13][C:14]1[CH:15]=[CH:16][C:17]([N:23]2[N:27]=[CH:26][CH:25]=[N:24]2)=[C:18]([CH:22]=1)[C:19](O)=[O:20]>C1(C)C=CC=CC=1>[CH3:11][C@@H:10]1[O:3][CH:2]([C:1]([O:5][CH2:6][CH3:7])=[O:4])[N:8]([C:19](=[O:20])[C:18]2[CH:22]=[C:14]([CH3:13])[CH:15]=[CH:16][C:17]=2[N:23]2[N:27]=[CH:26][CH:25]=[N:24]2)[CH2:9]1

Participants

5

Reactant 3

HCID 70211Ethyl oxoacetateHCID 7311736(S)-(+)-1-Aminopropan-2-olHCID 532601655-methyl-2-(2H-1,2,3-triazol-2-yl)benzoic acid

Product 1

HCID 118020508HCID 118020508, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

By using ethyl glyoxylate (polymer type, a solution of 47% toluene) (0.5 mL, 2.4 mmol), (2S)-1-aminopropan-2-ol (0.18 mL, 2.4 mmol) and 5-methyl-2-(2H-1,2,3-triazol-2-yl)benzoic acid (0.20 g, 0.98 mmol), the same procedure as in Reference Example 1 was carried out to obtain the title compound (0.11 g) (colorless oil).

Sources & evidence

ORD record
ord-6eecf035b7b148719a3aefd977e9d361
Source dataset
uspto-grants-2016_02
Patent number
US09266870B2

Reaction notes

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