Ammonia → Diethyl (4-{[4-({7-[1-(3-hydroxypropyl)-1H-pyrazol-4-yl]-2-methyl-3-oxo-2,3-dihydro-1H-isoindol-4-yl}amino)-5-(trifluoromethyl)pyrimidin-2-yl]amino}-3-methoxybenzyl)phosphonate
Reaction equation
[CH3:59][OH:60].[Cl:1][c:2]1[n:3][c:4]([NH:12][c:13]2[c:14]([O:28][CH3:29])[cH:15][c:16]([CH2:17][P:18]([O:19][CH2:20][CH3:21])([O:22][CH2:23][CH3:24])=[O:25])[cH:26][cH:27]2)[n:5][cH:6][c:7]1[C:8]([F:9])([F:10])[F:11].[F:51][C:52]([F:53])([F:54])[C:55]([OH:56])=[O:57].[NH2:30][c:31]1[cH:32][cH:33][c:34](-[c:42]2[cH:43][n:44][n:45]([CH2:47][CH2:48][CH2:49][OH:50])[cH:46]2)[c:35]2[c:39]1[C:38](=[O:40])[N:37]([CH3:41])[CH2:36]2.[NH3:58]>>[c:2]1([NH:30][c:31]2[cH:32][cH:33][c:34](-[c:42]3[cH:43][n:44][n:45]([CH2:47][CH2:48][CH2:49][OH:50])[cH:46]3)[c:35]3[c:39]2[C:38](=[O:40])[N:37]([CH3:41])[CH2:36]3)[n:3][c:4]([NH:12][c:13]2[c:14]([O:28][CH3:29])[cH:15][c:16]([CH2:17][P:18]([O:19][CH2:20][CH3:21])([O:22][CH2:23][CH3:24])=[O:25])[cH:26][cH:27]2)[n:5][cH:6][c:7]1[C:8]([F:9])([F:10])[F:11]Participants
6
Reactant 5
Product 1
Sources & evidence
- ORD record
- ord-a8007b4cf36b4798a191471976795b1d
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (6/10)
Reaction notes
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