Hydrochloric Acid → HCID 67973995, compound

HRID 1777537Notes

Reaction equation

HRID 1777537 reaction equation
[OH-].[Na+].[F:3][C:4]1[CH:5]=[C:6]([CH:11]=[CH:12][C:13]=1[CH2:14][C:15]1[CH:20]=[CH:19][CH:18]=[C:17]([F:21])[CH:16]=1)[C:7]([O:9]C)=[O:8].Cl>C(O)C>[F:3][C:4]1[CH:5]=[C:6]([CH:11]=[CH:12][C:13]=1[CH2:14][C:15]1[CH:20]=[CH:19][CH:18]=[C:17]([F:21])[CH:16]=1)[C:7]([OH:9])=[O:8]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 67973755HCID 67973755, compound

Product 1

HCID 67973995HCID 67973995, compoundYield 82.1%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of sodium hydroxide 2M (1 mL; 2 mmol) was added to a solution of methyl 3-fluoro-4-(3-fluorobenzyl)benzoate (0.143 g; 0.545 mmol) in ethanol (1 mL). The mixture was stirred at room temperature for 1 hour and the pH of the solution was adjusted to 1 by addition of a solution of 6N hydrochloric acid. The precipitate was collected by filtration and dried under reduced pressure to give 0.111 g (82%) of 3-fluoro-4-(3-fluorobenzyl)benzoic acid as a white solid.

Workup

  1. filtrationThe precipitate was collected by filtration
  2. customdried under reduced pressure

Sources & evidence

ORD record
ord-00358b7fe00740d3bc9e8c528c58bbe0
Source dataset
uspto-grants-2016_02
Patent number
US09266832B2

Reaction notes

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