反应详情

A mixture of 3-fluorophenylboronic acid (0.319 g; 2.28 mmol), methyl 5-(bromomethyl)picolinate (0.350 g; 0.230 mmol), tetrakis-(triphenylphosphine)-palladium(0) (0.175; 0.152 mmol) and N,N diisopropylethylamine (0.524 g; 3.04 mmol) in dimethoxyethane (9 mL) and water (3 mL) was irradiated in a microwave oven at 130° C. for 20 minutes. The resulting solution was partitioned between water and ethyl acetate. The organic layer was separated and concentrated under reduced pressure. The crude residue was purified by flash chromatography on silica gel (eluent 1 to 10% ethyl acetate in dichlomethane) to afford 0.149 g (40%) of the title compound as a yellow oil.

1. customwas irradiated in a microwave oven at 130° C. for 20 minutes
2. customThe resulting solution was partitioned between water and ethyl acetate
3. customThe organic layer was separated
4. concentrationconcentrated under reduced pressure
5. customThe crude residue was purified by flash chromatography on silica gel (eluent 1 to 10% ethyl acetate in dichlomethane)