反应详情

温度

70 °C

A mixture of 3-(2-azidoethyl)-2-(triethylsilyl)-5-(trifluoromethyl)-1H-indole (0.400 g; 1.09 mmol) and triphenylphosphine (0.427 g; 1.63 mmol) in methanol (5 mL) was stirred at 70° C. for 2 hours. The reaction mixture was concentrated under reduced pressure and the crude material was dissolved in a solution of tetrabutylamonium fluoride (3.26 mL, 1M) in THF, stirred at room temperature for 36 hours, and concentrated under reduced pressure. The crude material was used without any further purification.

1. concentrationThe reaction mixture was concentrated under reduced pressure
2. dissolutionthe crude material was dissolved in a solution of tetrabutylamonium fluoride (3.26 mL, 1M) in THF
3. stirringstirred at room temperature for 36 hours
4. concentrationconcentrated under reduced pressure
5. customThe crude material was used without any further purification