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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1777578Generated: November 2, 2026

Pyridine → Methyl 4-(3-fluorophenoxy)benzoate

https://huagongshe.com/reaction/1777578

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPyridineHCID 1049—
ReactantMethylparabenHCID 7456—
Reactant3-Fluorophenylboronic acidHCID 2733986—
CatalystCupric acetateHCID 8895—
SolventDichloromethaneHCID 6344—
ProductMethyl 4-(3-fluorophenoxy)benzoateHCID 67973924—

Reaction Steps

A mixture of methyl 4-hydroxybenzoate (0.400 g; 2.63 mmol), 3-fluorobenzene boronic acid (0.735 g; 5.26 mmol), copper acetate (0.955 g; 5.26 mmol) and pyridine (0.425 mL; 5.26 mmol) in dichloromethane (15 mL) was stirred at room temperature overnight. The reaction mixture was filtered and concentrated under reduced pressure.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09266832B2
Source datasetuspto-grants-2016_02
ORD IDord-cb1f2ccb3941421198d896d3ed1b911d
Source noteuspto-grants-2016_02