benzyl 2-(4-((dimethylamino)methyl)-3,5-dimethyl-1H-pyrazol-1-yl)acetate → benzyl 2-(3,5-dimethyl-1H-pyrazol-1-yl)acetate

HRID 1777753Notes

Reaction equation

HRID 1777753 reaction equation
CN(C[C:5]1[C:6]([CH3:22])=[N:7][N:8]([CH2:11][C:12]([O:14][CH2:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)=[O:13])[C:9]=1[CH3:10])C>CCO>[CH3:22][C:6]1[CH:5]=[C:9]([CH3:10])[N:8]([CH2:11][C:12]([O:14][CH2:15][C:16]2[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=2)=[O:13])[N:7]=1

Participants

3

Reactant 1

HCID 89726461benzyl 2-(4-((dimethylamino)methyl)-3,5-dimethyl-1H-pyrazol-1-yl)acetate

Product 1

HCID 52463841benzyl 2-(3,5-dimethyl-1H-pyrazol-1-yl)acetate

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The final compound was prepared using a method analogous to that of Example 14 step 14.2, benzyl 2-(4-((dimethylamino)methyl)-3,5-dimethyl-1H-pyrazol-1-yl)acetate replacing intermediate 14.1 and using EtOH instead of MeOH/AcOH. LC-MS (B): tR=0.23 min; [M+H]+: 212.17.

Sources & evidence

ORD record
ord-a63e5f18b17b4fbb88c9008d94eef1ee
Source dataset
uspto-grants-2016_02
Patent number
US09266876B2

Reaction notes

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