6-Aminopyridine-3,4-dicarbonitrile → N-(4,5-dicyanopyridin-2-yl)-7-(dimethoxymethyl)-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxamide
Reaction equation
[CH3:1][O:2][CH:3]([O:23][CH3:24])[C:4]1[N:13]=[C:12]2[C:7]([CH2:8][CH2:9][CH2:10][N:11]2[C:14]([O:16]C2C=CC=CC=2)=O)=[CH:6][CH:5]=1.[NH2:25][C:26]1[N:31]=[CH:30][C:29]([C:32]#[N:33])=[C:28]([C:34]#[N:35])[CH:27]=1>>[C:34]([C:28]1[C:29]([C:32]#[N:33])=[CH:30][N:31]=[C:26]([NH:25][C:14]([N:11]2[C:12]3[C:7](=[CH:6][CH:5]=[C:4]([CH:3]([O:2][CH3:1])[O:23][CH3:24])[N:13]=3)[CH2:8][CH2:9][CH2:10]2)=[O:16])[CH:27]=1)#[N:35]Participants
3
Procedure
From intermediate 3 and 6-aminopyridine-3,4-dicarbonitrile, reacted in an analogous manner to the preparation of intermediate 2. (UPLC-MS 1) tR 1.15 min, ESI-MS 379.1 [M+H]+.
Sources & evidence
- ORD record
- ord-a30dc5df28684dddab6ec1b3c6dad100
- Source dataset
- uspto-grants-2016_02
- Patent number
- US09266883B2
Reaction notes
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