3-Furanol, tetrahydro- → (Racemic) 6-amino-4-((tetrahydrofuran-3-yl)oxy)nicotinonitrile

HRID 1777866Notes

Reaction equation

HRID 1777866 reaction equation
[NH2:1][C:2]1[CH:9]=[C:8](Cl)[C:5]([C:6]#[N:7])=[CH:4][N:3]=1.[O:11]1[CH2:15][CH2:14][CH:13]([OH:16])[CH2:12]1>>[NH2:1][C:2]1[CH:9]=[C:8]([O:16][CH:13]2[CH2:14][CH2:15][O:11][CH2:12]2)[C:5]([C:6]#[N:7])=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 99603-Furanol, tetrahydro-HCID 219492196-Amino-4-chloro-3-pyridinecarbonitrile

Product 1

HCID 118036146(Racemic) 6-amino-4-((tetrahydrofuran-3-yl)oxy)nicotinonitrile

Procedure

From intermediate 16 and racemic tetrahydrofuran-3-ol, reacted in an analogous manner to the preparation of intermediate 20. (UPLC-MS 3) tR 0.48 min, ESI-MS 206.1 [M+H]+.

Sources & evidence

ORD record
ord-7af46030e15c41349ef898e0aa057416
Source dataset
uspto-grants-2016_02
Patent number
US09266883B2

Reaction notes

Loading…