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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1777866Generated: October 27, 2026

3-Furanol, tetrahydro- → (Racemic) 6-amino-4-((tetrahydrofuran-3-yl)oxy)nicotinonitrile

https://huagongshe.com/reaction/1777866

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-Furanol, tetrahydro-HCID 9960—
Reactant6-Amino-4-chloro-3-pyridinecarbonitrileHCID 21949219—
Product(Racemic) 6-amino-4-((tetrahydrofuran-3-yl)oxy)nicotinonitrileHCID 118036146—

Reaction Steps

From intermediate 16 and racemic tetrahydrofuran-3-ol, reacted in an analogous manner to the preparation of intermediate 20. (UPLC-MS 3) tR 0.48 min, ESI-MS 206.1 [M+H]+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09266883B2
Source datasetuspto-grants-2016_02
ORD IDord-7af46030e15c41349ef898e0aa057416
Source noteuspto-grants-2016_02