(Oxetan-2-yl)methanol → 6-Amino-4-(oxetan-2-ylmethoxy)nicotinonitrile

HRID 1777880Notes

Reaction equation

HRID 1777880 reaction equation
[NH2:1][C:2]1[CH:9]=[C:8](Cl)[C:5]([C:6]#[N:7])=[CH:4][N:3]=1.[O:11]1[CH2:14][CH2:13][CH:12]1[CH2:15][OH:16]>>[NH2:1][C:2]1[CH:9]=[C:8]([O:16][CH2:15][CH:12]2[CH2:13][CH2:14][O:11]2)[C:5]([C:6]#[N:7])=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 12284142(Oxetan-2-yl)methanolHCID 219492196-Amino-4-chloro-3-pyridinecarbonitrile

Product 1

HCID 1180363096-Amino-4-(oxetan-2-ylmethoxy)nicotinonitrile

Procedure

From intermediate 16 and oxetan-2-ylmethanol, reacted in an analogous manner to the preparation of intermediate 34. (UPLC-MS 3) tR 0.45 min; ESI-MS 206.1 [M+H]+.

Sources & evidence

ORD record
ord-b0134d99aceb4c3d86830e93327a5cf6
Source dataset
uspto-grants-2016_02
Patent number
US09266883B2

Reaction notes

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