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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1777880Generated: October 31, 2026

(Oxetan-2-yl)methanol → 6-Amino-4-(oxetan-2-ylmethoxy)nicotinonitrile

https://huagongshe.com/reaction/1777880

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(Oxetan-2-yl)methanolHCID 12284142—
Reactant6-Amino-4-chloro-3-pyridinecarbonitrileHCID 21949219—
Product6-Amino-4-(oxetan-2-ylmethoxy)nicotinonitrileHCID 118036309—

Reaction Steps

From intermediate 16 and oxetan-2-ylmethanol, reacted in an analogous manner to the preparation of intermediate 34. (UPLC-MS 3) tR 0.45 min; ESI-MS 206.1 [M+H]+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09266883B2
Source datasetuspto-grants-2016_02
ORD IDord-b0134d99aceb4c3d86830e93327a5cf6
Source noteuspto-grants-2016_02