HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrahydro-4H-pyran-4-ol → 6-amino-4-((tetrahydro-2H-pyran-4-yl)oxy)nicotinonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrahydro-4H-pyran-4-ol | HCID 74956 | — |
| Reactant | 6-Amino-4-fluoronicotinonitrile | HCID 118036901 | — |
| Product | 6-amino-4-((tetrahydro-2H-pyran-4-yl)oxy)nicotinonitrile | HCID 118036407 | — |
Reaction Steps
From intermediate 21 and tetrahydro-2H-pyran-4-ol, reacted in an analogous manner to the preparation of intermediate 45. (UPLC-MS 3) tR 0.53 min; ESI-MS 220.1 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09266883B2 |
| Source dataset | uspto-grants-2016_02 |
| ORD ID | ord-a5a2faed4b2749e4818795a46fd3bcf5 |
| Source note | uspto-grants-2016_02 |