Tetrahydro-4H-pyran-4-ol → 6-amino-4-((tetrahydro-2H-pyran-4-yl)oxy)nicotinonitrile

HRID 1777895Notes

Reaction equation

HRID 1777895 reaction equation
[NH2:1][C:2]1[CH:9]=[C:8](F)[C:5]([C:6]#[N:7])=[CH:4][N:3]=1.[O:11]1[CH2:16][CH2:15][CH:14]([OH:17])[CH2:13][CH2:12]1>>[NH2:1][C:2]1[CH:9]=[C:8]([O:17][CH:14]2[CH2:15][CH2:16][O:11][CH2:12][CH2:13]2)[C:5]([C:6]#[N:7])=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 74956Tetrahydro-4H-pyran-4-olHCID 1180369016-Amino-4-fluoronicotinonitrile

Product 1

HCID 1180364076-amino-4-((tetrahydro-2H-pyran-4-yl)oxy)nicotinonitrile

Procedure

From intermediate 21 and tetrahydro-2H-pyran-4-ol, reacted in an analogous manner to the preparation of intermediate 45. (UPLC-MS 3) tR 0.53 min; ESI-MS 220.1 [M+H]+.

Sources & evidence

ORD record
ord-a5a2faed4b2749e4818795a46fd3bcf5
Source dataset
uspto-grants-2016_02
Patent number
US09266883B2

Reaction notes

Loading…