(2S)-1-Methyl-2-pyrrolidinemethanol → HCID 118036524, compound

HRID 1777901Notes

Reaction equation

HRID 1777901 reaction equation
[NH2:1][C:2]1[CH:9]=[C:8](F)[C:5]([C:6]#[N:7])=[CH:4][N:3]=1.[CH3:11][N:12]1[CH2:16][CH2:15][CH2:14][C@H:13]1[CH2:17][OH:18]>>[NH2:1][C:2]1[CH:9]=[C:8]([O:18][CH2:17][C@@H:13]2[CH2:14][CH2:15][CH2:16][N:12]2[CH3:11])[C:5]([C:6]#[N:7])=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 643492(2S)-1-Methyl-2-pyrrolidinemethanolHCID 1180369016-Amino-4-fluoronicotinonitrile

Product 1

HCID 118036524HCID 118036524, compound

Procedure

From intermediate 21 and (S)-(1-methylpyrrolidin-2-yl)methanol, reacted in an analogous manner to the preparation of intermediate 47. (UPLC-MS 3) tR 0.30 min; ESI-MS 233.2 [M+H]+.

Sources & evidence

ORD record
ord-a378eda7b4ee46a6955c6aa3a4941ab3
Source dataset
uspto-grants-2016_02
Patent number
US09266883B2

Reaction notes

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