4-Aminotetrahydropyran → HCID 118036482, compound

HRID 1777907Notes

Reaction equation

HRID 1777907 reaction equation
[NH2:1][C:2]1[CH:9]=[C:8](F)[C:5]([C:6]#[N:7])=[CH:4][N:3]=1.[O:11]1[CH2:16][CH2:15][CH:14]([NH2:17])[CH2:13][CH2:12]1>>[NH2:1][C:2]1[CH:9]=[C:8]([NH:17][CH:14]2[CH2:15][CH2:16][O:11][CH2:12][CH2:13]2)[C:5]([C:6]#[N:7])=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 4192234-AminotetrahydropyranHCID 1180369016-Amino-4-fluoronicotinonitrile

Product 1

HCID 118036482HCID 118036482, compound

Procedure

From intermediate 21 and racemic tetrahydro-2H-pyran-4-amine, reacted in an analogous manner to the preparation of intermediate 49. (UPLC-MS 3) tR 0.36 min; ESI-MS 219.1 [M+H]+.

Sources & evidence

ORD record
ord-3aba19ea18b24b6fa4952f3b98dc440f
Source dataset
uspto-grants-2016_02
Patent number
US09266883B2

Reaction notes

Loading…