2-Propanol, 1,1,1-trifluoro-3-methoxy-, (2R)- → HCID 118036516, compound

HRID 1777926Notes

Reaction equation

HRID 1777926 reaction equation
[NH2:1][C:2]1[CH:9]=[C:8](F)[C:5]([C:6]#[N:7])=[CH:4][N:3]=1.[F:11][C:12]([F:19])([F:18])[C@H:13]([OH:17])[CH2:14][O:15][CH3:16]>>[NH2:1][C:2]1[CH:9]=[C:8]([O:17][C@H:13]([CH2:14][O:15][CH3:16])[C:12]([F:19])([F:18])[F:11])[C:5]([C:6]#[N:7])=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 866395432-Propanol, 1,1,1-trifluoro-3-methoxy-, (2R)-HCID 1180369016-Amino-4-fluoronicotinonitrile

Product 1

HCID 118036516HCID 118036516, compound

Procedure

From intermediate 21 and (R)-1,1,1-trifluoro-3-methoxypropan-2-ol, reacted in an analogous manner to the preparation of intermediate 68. UPLC-MS 3: Rt=0.75 min; MS m/z [M+H]+ 262.1;

Sources & evidence

ORD record
ord-a2346496df3d49569bd946bbe0f23782
Source dataset
uspto-grants-2016_02
Patent number
US09266883B2

Reaction notes

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