2-(Trifluoromethoxy)ethanamine → 6-Amino-4-((2-(trifluoromethoxy)ethyl)amino)nicotinonitrile

HRID 1777959Notes

Reaction equation

HRID 1777959 reaction equation
[NH2:1][C:2]1[CH:9]=[C:8](F)[C:5]([C:6]#[N:7])=[CH:4][N:3]=1.[F:11][C:12]([F:18])([F:17])[O:13][CH2:14][CH2:15][NH2:16]>>[NH2:1][C:2]1[CH:9]=[C:8]([NH:16][CH2:15][CH2:14][O:13][C:12]([F:18])([F:17])[F:11])[C:5]([C:6]#[N:7])=[CH:4][N:3]=1

Participants

3

Reactant 2

HCID 105586452-(Trifluoromethoxy)ethanamineHCID 1180369016-Amino-4-fluoronicotinonitrile

Product 1

HCID 1180364246-Amino-4-((2-(trifluoromethoxy)ethyl)amino)nicotinonitrile

Procedure

From intermediate 21 and 2-(trifluoromethoxy)ethanamine, reacted in an analogous manner to the preparation of intermediate 102. (UPLC-MS 3) Rt=0.54 min; MS m/z [M+H]+ 247.

Sources & evidence

ORD record
ord-d8229281c80945789a053ca913d6f7f8
Source dataset
uspto-grants-2016_02
Patent number
US09266883B2

Reaction notes

Loading…