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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1777959Generated: November 1, 2026

2-(Trifluoromethoxy)ethanamine → 6-Amino-4-((2-(trifluoromethoxy)ethyl)amino)nicotinonitrile

https://huagongshe.com/reaction/1777959

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-(Trifluoromethoxy)ethanamineHCID 10558645—
Reactant6-Amino-4-fluoronicotinonitrileHCID 118036901—
Product6-Amino-4-((2-(trifluoromethoxy)ethyl)amino)nicotinonitrileHCID 118036424—

Reaction Steps

From intermediate 21 and 2-(trifluoromethoxy)ethanamine, reacted in an analogous manner to the preparation of intermediate 102. (UPLC-MS 3) Rt=0.54 min; MS m/z [M+H]+ 247.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09266883B2
Source datasetuspto-grants-2016_02
ORD IDord-d8229281c80945789a053ca913d6f7f8
Source noteuspto-grants-2016_02