Hydrochloric Acid → HCID 20495621, compound

HRID 1778011Notes

Reaction equation

HRID 1778011 reaction equation
Cl.C(OC([NH:9][CH2:10][CH2:11][S:12][CH2:13][C:14]([O:16][CH2:17][CH3:18])=[O:15])=O)(C)(C)C>O1CCOCC1>[NH2:9][CH2:10][CH2:11][S:12][CH2:13][C:14]([O:16][CH2:17][CH3:18])=[O:15]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 118036756HCID 118036756, compound2×

Product 1

HCID 20495621HCID 20495621, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

HCl (4M in dioxane, 6 mL, 24.00 mmol) was added to a solution of ethyl 2-((2-((tert-butoxycarbonyl)amino)ethyl)thio)acetate (intermediate 211, 765 mg, 2.805 mmol) in dioxane (4 ml) at room temperature for 19 h. The reaction mixture was concentrated to yield the title compound as a reddish oil. (UPLC-MS 3) ESI-MS 165.1 [M+H]+. 1H NMR (600 MHz, DMSO-d6) δ 8.06 (s, 2H), 4.16-4.09 (m, 2H), 3.46 (s, 2H), 3.04-2.98 (m, 2H), 2.83 (t, 2H), 1.22 (t, 3H).

Workup

  1. concentrationThe reaction mixture was concentrated

Sources & evidence

ORD record
ord-1c649795d705463895b985a3ca68e26c
Source dataset
uspto-grants-2016_02
Patent number
US09266883B2

Reaction notes

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