2-Thiophenemethanol → 6-Amino-4-(thiophen-2-ylmethoxy)nicotinonitrile

HRID 1778033Notes

Reaction equation

HRID 1778033 reaction equation
[NH2:1][C:2]1[CH:9]=[C:8](F)[C:5]([C:6]#[N:7])=[CH:4][N:3]=1.[S:11]1[CH:15]=[CH:14][CH:13]=[C:12]1[CH2:16][OH:17].NC1C=C(OC(C)C)C(C#N)=CN=1>>[NH2:1][C:2]1[CH:9]=[C:8]([O:17][CH2:16][C:12]2[S:11][CH:15]=[CH:14][CH:13]=2)[C:5]([C:6]#[N:7])=[CH:4][N:3]=1

Participants

4

Reactant 3

HCID 694672-ThiophenemethanolHCID 1180369016-Amino-4-fluoronicotinonitrileHCID 1180369706-Amino-4-isopropoxynicotinonitrile

Product 1

HCID 1180368296-Amino-4-(thiophen-2-ylmethoxy)nicotinonitrile

Procedure

From intermediate 21 and thiophen-2-ylmethanol, synthesised in an analogous manner to intermediate 97, the title compound was obtained as a pale-yellow solid. (UPLC-MS 3) tR 0.75; ESI-MS 232.1 [M+H]+.

Sources & evidence

ORD record
ord-b4bef3b6aff9428bb2cc26e8117e9719
Source dataset
uspto-grants-2016_02
Patent number
US09266883B2

Reaction notes

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