HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Thiophenemethanol → 6-Amino-4-(thiophen-2-ylmethoxy)nicotinonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Thiophenemethanol | HCID 69467 | — |
| Reactant | 6-Amino-4-fluoronicotinonitrile | HCID 118036901 | — |
| Reactant | 6-Amino-4-isopropoxynicotinonitrile | HCID 118036970 | — |
| Product | 6-Amino-4-(thiophen-2-ylmethoxy)nicotinonitrile | HCID 118036829 | — |
Reaction Steps
From intermediate 21 and thiophen-2-ylmethanol, synthesised in an analogous manner to intermediate 97, the title compound was obtained as a pale-yellow solid. (UPLC-MS 3) tR 0.75; ESI-MS 232.1 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09266883B2 |
| Source dataset | uspto-grants-2016_02 |
| ORD ID | ord-b4bef3b6aff9428bb2cc26e8117e9719 |
| Source note | uspto-grants-2016_02 |