Hydrochloric Acid → HCID 118036202, compound

HRID 1778076Notes

Reaction equation

HRID 1778076 reaction equation
[C:1]([C:3]1[C:4]([O:27][CH3:28])=[CH:5][C:6]([NH:9][C:10]([N:12]2[C:21]3[C:16](=[CH:17][CH:18]=[C:19]([CH:22](OC)[O:23]C)[N:20]=3)[CH2:15][CH2:14][CH2:13]2)=[O:11])=[N:7][CH:8]=1)#[N:2].Cl>>[C:1]([C:3]1[C:4]([O:27][CH3:28])=[CH:5][C:6]([NH:9][C:10]([N:12]2[C:21]3[C:16](=[CH:17][CH:18]=[C:19]([CH:22]=[O:23])[N:20]=3)[CH2:15][CH2:14][CH2:13]2)=[O:11])=[N:7][CH:8]=1)#[N:2]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 118036290HCID 118036290, compound2×

Product 1

HCID 118036202HCID 118036202, compound

Procedure

N-(5-cyano-4-methoxypyridin-2-yl)-7-(dimethoxymethyl)-3,4-dihydro-1,8-naphthyridine-1(2H)-carboxamide (intermediate 2B, 36 mg, 0.094 mmol) was treated with HCl (4 M in dioxane, 2 ml, 65.8 mmol). The solution was stirred at room temperature for 1 h. The reaction mixture was concentrated under vacuum. The residue was triturated with EtOAc to furnish the title compound as a white solid.

Workup

  1. concentrationThe reaction mixture was concentrated under vacuum
  2. customThe residue was triturated with EtOAc

Sources & evidence

ORD record
ord-be1d2261b2a64843b1e97c8de3b05569
Source dataset
uspto-grants-2016_02
Patent number
US09266883B2

Reaction notes

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