HRID1778111

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6228

N,N-Dimethylformamide

C3H7NO

结构：COC(OC)c1ccc2c(n1)N(C(=O)Nc1ccc(C#N)cn1)CCCC2

HCID118037151

未命名化合物

HCID125470513

未命名化合物

PRODUCTS

生成物

结构：CC(C)Oc1cc(NC(=O)N2c3nc(C=O)c(CN4CCN(C)CC4=O)cc3CC[C@@H]2C)ncc1C#N

HCID118036534

未命名化合物

PROCEDURE

实验过程

From intermediates 96 and 268, coupled and deprotected in an analogous manner to intermediate 236, but using DMF instead of THF, and Example 201. The title compound was obtained as a light brown solid.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-4954b20e3c4e49e9b52d94086c66a9e4
来源数据集: uspto-grants-2016_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09266883B2
来源说明: uspto-grants-2016_02

反应 SMILES

C1(O[C:8](=[O:22])[NH:9][C:10]2[CH:15]=[C:14]([O:16][CH:17]([CH3:19])[CH3:18])[C:13]([C:20]#[N:21])=[CH:12][N:11]=2)C=CC=CC=1.C(C1C=CC(NC([N:34]2[CH2:40][CH2:39][CH2:38][CH2:37][C:36]3[CH:41]=[CH:42][C:43]([CH:45]([O:48]C)OC)=[N:44][C:35]2=3)=O)=NC=1)#N.[CH3:50][N:51]([CH:53]=[O:54])[CH3:52]>>[C:20]([C:13]1[C:14]([O:16][CH:17]([CH3:18])[CH3:19])=[CH:15][C:10]([NH:9][C:8]([N:34]2[C:35]3[C:36](=[CH:41][C:42]([CH2:50][N:51]4[CH2:52][CH2:52][N:51]([CH3:53])[CH2:50][C:53]4=[O:54])=[C:43]([CH:45]=[O:48])[N:44]=3)[CH2:37][CH2:38][C@@H:40]2[CH3:39])=[O:22])=[N:11][CH:12]=1)#[N:21]