HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 84016145, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Lithium Hydroxide | HCID 3939 | — |
| Reactant | 1-Methyl-5-phenoxy-1H-pyrazole-4-carboxylic acid ethyl ester | HCID 86718550 | — |
| Solvent | MeOH tetrahydrofuran | HCID 21899815 | — |
| Product | HCID 84016145 | HCID 84016145 | — |
Reaction Steps
1-Methyl-5-phenoxy-1H-pyrazole-4-carboxylic acid ethyl ester (22.6 g; 91.4 mmol) is dissolved in THF/MeOH (1/1) and LiOH in water (7.67 g; 183 mmol) is added. After 16 hours at ambient temperature the reaction mixture is washed with EtOAc. The aqueous layer is acidified with 1 N HCl and extracted with EtOAc. The organic layer is dried and evaporated.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09266891B2 |
| Source dataset | uspto-grants-2016_02 |
| ORD ID | ord-5f092d773f20464aab47acfdc40b6913 |
| Source note | uspto-grants-2016_02 |