反应详情

1-Methyl-5-phenoxy-1H-pyrazole-4-carboxylic acid ethyl ester (22.6 g; 91.4 mmol) is dissolved in THF/MeOH (1/1) and LiOH in water (7.67 g; 183 mmol) is added. After 16 hours at ambient temperature the reaction mixture is washed with EtOAc. The aqueous layer is acidified with 1 N HCl and extracted with EtOAc. The organic layer is dried and evaporated.

1. washAfter 16 hours at ambient temperature the reaction mixture is washed with EtOAc
2. extractionextracted with EtOAc
3. customThe organic layer is dried
4. customevaporated