反应详情

tert-Butyldimethylsilyl trifluoromethanesulfonate (4.47 g) was added to a solution of 2-(3-bromofuran-2-yl)-ethanol (Intermediate 35, 2.94 g) and pyridine (2.43 g) in DCM (40 mL) and the mixture was stirred for 90 minutes. Water was added and the organic layer was separated, dried (Na2SO4) and filtered. The filtrate was evaporated to dryness and the residue was purified by chromatography on silica, eluting with a mixture of DCM and cyclohexane with a gradient of 0-25% to give [2-(3-bromo-furan-2-yl)-ethoxy]-tert-butyldimethylsilane (3.98 g) as a colourless oil. The material was used without further characterisation.

1. customthe organic layer was separated
2. dry with materialdried (Na2SO4)
3. filtrationfiltered
4. customThe filtrate was evaporated to dryness
5. customthe residue was purified by chromatography on silica
6. washeluting with a mixture of DCM and cyclohexane with a gradient of 0-25%